Ultra-Micronized Palmitoylethanolamide (PEA-um)

What is ultra-micronized palmitoylethanolamide (PEA-um)?

Ultra-micronized palmitoylethanolamide (PEA-um) (brand name Redonyl® Ultra) is a nutraceutical used to support skin health in dogs and cats. This medication should only be used under the supervision of a veterinarian.

The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before being sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately. The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” 

Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer.  These products are not tested by Health Canada.

Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy. 

Although the information in this handout may be helpful, it also may be incomplete and may not represent the full range of effects the supplement could have on your pet.

How do I give my pet PEA-um?

PEA-um comes in oral chewable and powder forms. 

• Chews and powder are given orally (by mouth). 
• This supplement can be given with food.
• Give this nutraceutical to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects from PEA-um?

PEA-um may cause the following side effects:

• vomiting, diarrhea, and stomach pain

The following reactions are rare; if they occur, contact your veterinarian immediately:

• an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. 

Are there any risk factors for this medication?

• This medication should be AVOIDED in animals with known allergic reactions to any component. 
• This medication should be used with CAUTION in pregnant or nursing dogs. 

Are there any drug interactions I should be aware of?

No known drug interactions have been reported for this medication. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule a follow-up visit after the course of medication is complete to ensure the condition has been cleared and/or do additional testing to ensure this is the right medication for the type of condition present. In this case, follow your veterinarian’s directions.

How do I store PEA-um?

• Store the medication in its original container, protected from light and moisture.
• Store at room temperature. 
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.